Therapeutic Ultrasound

Mission

The therapeutic ultrasound Laboratory was founded in September of 2012. The mission of the Laboratory is to perform research in the field of MRI guidance of therapeutic ultrasound mainly for applications in the brain. The laboratory specializes in the design of MRI compatible robots MRI. The strategic objective of the Laboratory is to create other applications of therapeutic ultrasound in medicine. The Laboratory includes complete equipment and has no dependency on any other laboratories. Head of the lab is Christakis Damianou (associate professor) who has 22 years of experience in this field and has participated in 24 research projects. The lab is housed in the Stoa Lanitis building.

Grants

  • TOURISMED
  • TOURISMED Summary
  • PROSTASONIC
  • FUSROBOT
  • ‘Destruction of atherosclerotic plaque using intense ultrasound’, Research Promotion foundation of Cyprus, Role: coordinator, Duration: 2012-2014.
  • ‘Parametric analysis of acoustical properties for optimizing Focused Ultrasound protocols under MRI guidance for the treatment of ischemic stroke’, role: coordinator, Duration: 2014-2016, funding, starting grant from CUT.
  • ‘MR compatible positioning device for multiple cancer targets’, Research promotion foundation, coordinator, 20,000 Euros, role: coordinator, Duration: 2016-2019, ΚΑΙΝΟΤΟΜΙΑ/ΕΥΡΕΣ/1114/03.
  • Continuous Regional Analysis Device for neonate Lung (CRADL), HORIZON 2020, PHC-18-2015, Topic: Establishing effectiveness of health care interventions in the paediatric population.1/1/16-1/1/19, Through Biomedical Research Foundation (BRF), CUT is represented by Christakis Damianou.

Photos

Journal Publications

-Yiallouras C., Mylonas N., Damianou C. ‘MR compatible positioning device for guiding a Focused ultrasound system for transrectal treatment of prostate cancer’, Computer-Assisted Radiology and Surgery, Vol. , (4),Page 745-753, 2014. DOI 10.1007/s11548-013-0964-x 2013.

-Damianou C., Christofi C., Mylonas N., Simulation of the Thermal and Mechanical Effects of a Planar Rectangular High Intensity Ultrasound Transducer to Be Used for Destroying Atherosclerotic Plaque Engineering, 2013, 5, 347-351, http://dx.doi.org/10.4236/eng.2013.510B070.

- Mylonas N., Damianou C. ‘A Prototype MR Compatible Positioning Device for Guiding a Focused Ultrasound System for the Treatment of Abdominal and Thyroid Cancer, International Journal of monitoring and surveillance technologies research, October-December, Vol.1 (4), pp. 48-61, 2013.

- Damianou C., Mylonas N., Ioannides K., ‘Sonothromblysis in Combination with Thrombolytic Drugs in a Rabbit Model Using MRI-Guidance’, Engineering, 2013, 5, 352-356, http://dx.doi.org/10.4236/eng.2013.510B071

-Damianou C., Hadjisavvas V., Ioannides K., ‘In vitro and in vivo evaluation of an MRI-guided focused ultrasound system for dissolving clots in combination with thrombolytic drugs’, Journal of Stroke and Cerebrovascular Diseases, Apr 2014. Epub 2014 Apr 29.
-Mylonas, N. and Damianou, C., MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain deseases. Int. J. Med. Robotics Comput. Assist. Surg., 2014 Mar;10(1):1-10. doi: 10.1002/rcs.1501. Epub 2013 Jun 7.

-Damianou C., Hadjisavvas V., Mylonas N., Couppis, A., Ioannides K., ‘MRI-Guided Sonothrombolysis of Rabbit Carotid Artery’, Journal of Stroke and Cerebrovascular Diseases, Vol 23 (2), pp. e113-21, 2014.

-Yiallouras C., Damianou C.’Review of MRI positioning devices for guiding focused ultrasound systems’, Int J Med Robotics Comput Assist Surg (2014), Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/rcs.1601.

- Menikou G, Dadakova T, Pavlina M, Bock M, Damianou C., MRI compatible head phantom for ultrasound surgery. Ultrasonics. 2015, Mar;57:144-52. doi: 10.1016/j.ultras.2014.11.004. Epub 2014 Nov 20.

-Damianou C., Christofi C., Mylonas N., ‘Removing atherosclerotic plaque created using high cholesterol diet in rabbit using ultrasound’, Journal of Therapeutic Ultrasound, (2015) 3:3, DOI 10.1186/s40349-015-0025-8.

-Yiallouras C., Ioannides C., Dadakova T., Pavlina M., Bock M., Damianou C., ‘Three axis MR conditional robot for high intensity focused ultrasound for treating prostate diseases’, Journal of Therapeutic Ultrasound, 2015, 3:2, DOI 10.1186/s40349-014-0023-2.
- Epaminonda E, Drakos T, Kalogirou C, Theodoulou M, Yiallouras C, Damianou C., MRI guided focused ultrasound robotic system for the treatment of gynaecological tumors, Int J Med Robot. 2015 Mar 25. doi: 10.1002/rcs.1653

-Yiannakou M, Trimikliniotis M, Yiallouras C, Damianou C. Evaluation of focused ultrasound algorithms: Issues for reducing pre-focal heating and treatment time. Ultrasonics. 65 (2016), pp. 145-153. doi: 10.1016/j.ultras.2015.10.007.

-Sagias G., Yiallouras C., Ioannides K., Damianou C., An MRI-conditional motion phantom for the evaluation of high-intensity focused ultrasound protocols, Int J Med Robot. , DOI: 10.1002/rcs.1709, 2015.
-C. Damianou, A. Couppis, ‘Feasibility study for removing calcified material using a planar rectangular ultrasound transducer, Journal of Ultrasound, 2016, 10.1007/s40477-015-0191-0.

-N. Papadopoulos, C. Damianou, ‘In vitro evaluation of focused ultrasound enhanced TNK-TPA mediated thrombolysis’ Journal of Stroke and Cerebrovascular Diseases, (in press), 2016.
-G. Menikou, C. Yiallouras, M. Yiannakou, C. Damianou, ‘MRI guided Focused Ultrasound Robotic System for the Treatment of bone cancer’, The International Journal of Medical Robotics and Computer Assisted Surgery, (in press), 2016.

People

Lead researcher
Christakis Damianou (Ph.D.)

Post docs
Marinos Yiannakou

Ph.D. students
Michalis Soteriou
Leonidas Ioannou
Tereza Alecou

Colaborators
Kleanthis Ioannides (M.D.)-Radiology
Ioasif Demitris- Veterinarian
Nicos Mylonas (Ph.D.)
Andreas Couppis (Ph.D.)

Alumni
George Menikou (with City University London)
Nicolas Papadopoulos (with City University London)
Christos Yiallouras (Ph.D.)- Post doc
George Sayias (M.Sc.)
Kiriaki Siakou (M.Sc.)
Michalis Trimikliniotis (M.Sc. with Liverpool university).
Eva Epaminonta, (B.Sc. thesis for Cyprus University of Technology).
Margarita Theodoulou, (B.Sc. thesis for Cyprus University of Technology, internship through Focused ultrasound foundation, 2014).
Drakos Theocharis, (B.Sc. thesis for Cyprus University of Technology).
Christina Kalogirou (B.Sc. thesis for Cyprus University of Technology).
Constantinos Psillis (internship through Focused ultrasound foundation, 2015).
Theocharous Irodotos (internship through Focused ultrasound foundation, 2015).
Nikolas Evripidou (internship through Focused ultrasound foundation, 2016).

Services

  • Acoustic attenuation measurement.
  • Acoustic absorption measurement.
  • Acoustic power measurement.
  • Acoustic intensity field measurement.
  • Diagnostic ultrasound
  • Therapeutic ultrasound
  • MRI compatible robots
  • 3 D printing with ABS