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Χριστάκης Δαμιανού

Χριστάκης Δαμιανού

Καθηγητής

christakis.damianou@cut.ac.cy

25002039

CV



Christakis Damianou received a B.Sc., M.Sc., and Ph.D. from the University of Arizona in Electrical engineering in 1988, 1990 and 1993 respectively. He was employed at the universities of Arizona, Indiana, Harvard and Frederick University. Since he returned to Cyprus (1995) his goal was to create a competitive laboratory in MRI guided focused ultrasound surgery.

Christakis Damianou joined Cyprus University of Technology in 2012 and he is currently full professor at the department of Electrical engineering. He teaches courses in the area of biomedical engineering (bioengineering, and medical imaging). His research interests include MRI guided therapeutic ultrasound and MRI [...]compatible robotics.

So far he was involved in 47 research programs, having the scientific coordination of 29 of them. Based on his research activities he published 216 scientific papers (90 of them are peer-reviewed) and 3 book chapters. Currently 3 Ph.D. students are working under the supervision of Dr. Damianou. So far 10 Ph.D. students have graduated under his supervision.

Since 1990 he is involved in the area of MRI guided Focused Ultrasound (MRgFUS) for medical applications. He is the co-inventor of MRgFUS which is a technology with many medical products globally. Intense ultrasound causes high temperatures (60-100 oC). Therefore this modality can be used to destroy cancer cells. This technology is focused and therefore only a specific target is destroyed, leaving the surrounding tissue unaffected. This technology was never commercialised in the past because there was no effective imaging method to monitor the therapy. Recently with the utilization of MRI, the heating due to ultrasound can be reliably monitored. The technology of MRgFUS is considered the best ablating modality of deep-seated targets and therefore is becoming an effective and attractive engineering-based surgical procedure.


  • Research Interests
  • Publications
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  • Teaching
  • Research Interests
  • Publications
  • Grants
  • Teaching

Research Interests

Simulation of thermal effects of high intensity focused ultrasound.

MRI monitoring of ultrasonic heating.

Ultrasonic tissue characterization.

MR-compatible robotics.

MRI coil design

Sonothrombolysis

Brain ablation

Skull phantoms

Motion phantoms

Publications

  1.  Hynynen K., Damianou C., Darkazanli A., Unger E., Schenck J., "The feasibility of using MRI to monitor and guide noninvasive ultrasound surgery", Ultrasound Med. Biol., Vol. 19 (1), pp. 91-92, 1992.
  2. Hynynen K., Damianou C., Alexander A., Unger E., Cline H., Schenck J., "Demonstration of MR-guided Noninvasive US surgery of the Kidney", Radiology, Vol.189(Suppl), pp. 224, 1993.
  3. Damianou C., Hynynen K., "Focal spacing and near-field heating during pulsed high temperature ultrasound therapy", Ultrasound Med. Biol., Vol. 19 (9), pp. 777-787, 1993.
  4. Damianou C., Hynynen K., "The effects of various physical parameters on the size and shape of necrosed tissue volume during ultrasound surgery", J. of Acoust. Soc. Am., Vol. 95 (3), pp. 1641-1649,1993.
  5. Hynynen K., Darkazanli A., Damianou C., Unger E., Schenck J., "Tissue thermometry during ultrasound exposure", Eur. Urol., Vol. 23 (suppl 1), pp. 12-16, 1993.
  6. Hynynen K., Darkazanli A., Damianou C., Unger E., Schenck J., "The usefulness of a contrast agent and Gradient-Recalled Acquisition in a Steady-State Imaging sequence for Magnetic Resonance Imaging-Guided noninvasive ultrasound surgery", Inv. Radiology, Vol. 29 (10), pp. 897-903, 1994.
  7. Vykhodtseva N., Hynynen K., Damianou C., "Pulse duration and peak intensity during focussed ultrasound surgery: Theoretical and experimental effects in rabbit brain in vivo", Ultrasound in Med. & Biol., Vol. 20 (9), pp. 987-1000, 1994.
  8. Vykhodtseva N., Hynynen K., Damianou C., "Histologic effects of high Intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in, vivo”, Ultrasound Med. Biol., Vol. 21(7), pp. 696-979, 1995.
  9. C. Damianou, “The role of High Intensity Focused Ultrasound in the treatment of Benign and Malignant Tumors, Cyprus Journal of Science and Technology, Vol. 1(1), pp. 101-104, 1995.
  10. Hynynen K., Damianou C., Collucci V., Unger E., Cline H., Jolesz F., "MR monitoring of focused utrasonic surgery of renal cortex: Experimental and simulation studies",  JMRI, Vol. 5(3), 259-266, 1995.
  11. Maass R., Damianou C., Sanghvi N., "Tissue temperature estimation during focussed ultrasound ablation using pulse-echo techniques",  Ultrasonic Imaging 17, 60-61, 1995.
  12. Damianou C., Hynynen K., Fan X., "Evaluation of accuracy of a theoretical model for predicting the necrosed tissue volume during focused ultrasound surgery", IEEE Trans. on Ultrasonics, Ferroelectrics, and frequency Control, Vol. 42 (2), pp. 182-187, 1995.
  13. Roberto Maass-Moreno, Damianou C. "Noninvasive temperature estimation in tissue via ultrasound echo shifts. Part I: Analytical model", Journal of Acoustical Society of America, Vol. 100, pp. 2414-2521, 1996.
  14. Roberto Maass-Moreno, Damianou C., and Narendra T. Sanghvi "Noninvasive temperature estimation in tissue via ultrasound echo shifts. Part II: in vitro study", Journal of Acoustical Society of America, Vol. 100, pp. 2522-2530, 1996.
  15. Damianou C., Sanghvi N., Fry F., Maass R., "Dependence of Ultrasonic attenuation and  absorption  in dog soft tissues on  temperature and thermal dose", Journal of Acoustical Society of America, Vol. 102(2), pp. 628-634, 1997.
  16. C.  Damianou, "MR gradient echo signal intensity sensitivity to temperature for rabbit and dog tissues in vitro", Cyprus Journal of Science and technology, Vol. 3 (1), pp. 95-106, 2000.
  17. C. Damianou, "In vitro and in vivo ablation of porcine renal tissues using High Intensity focused Ultrasound", Journal of Ultrasound in Medicine and Biology, Vol. 29 (9), pp. 1321-1330, 2003
  18. C. Damianou, M. Pavlou, O. Velev, K. Kyriakou, M. Trimikliniotis ‘High intensity focused ultrasound ablation of kidney guided by ΜRI’, Journal of Ultrasound in Medicine and Biology Vol. 30 (3), pp. 397-404, 2004
  19. C. Damianou “MRI monitoring of the effect of tissue interfaces in the penetration of high intensity focused ultrasound in kidney in vivo” Journal of Ultrasound in Medicine and Biology , Vol. 30 (9), pp. 1209-1215, 2004.
  20. C. Damianou, ‘MRI monitoring of ultrasonic cavitation’, The Cyprus journal of Science and Technology, Vol. 4 (1), pp. 52-62, 2004.
  21. Damianou, C., Ioannides, K., Milonas, ‘Positioning device for MRI-guided high intensity focused ultrasound system’, Computer-Assisted Radiology and Surgery, 2 (6) pp. 335-345, 2008.
  22. C. Damianou, Ioannides K., Hadjisavas V., Milonas N., Couppis A, Iosif D, ‘In vitro and in vivo brain ablation created by high intensity focused ultrasound and monitored by MRI’, IEEE Transaction on Ultrasonics, Ferroelectrics and Frequency Control, 56(6), pp. 1189-1198, 2009.
  23. Mylonas N., Ioannides K., Hadjisavvas V., Iosif D., Kyriacou P., Damianou C, ’Evaluation of fast spin echo MRI sequence for an MRI guided high intensity focused ultrasound system for in vivo rabbit liver ablation’ J. Biomedical Science and Engineering, 2010, 3, 241-246
  24. C. Damianou, Ioannides K., Hadjisavas V., Milonas N., Couppis A., D. Iosif, P. Kyriacou’ MRI monitoring of lesions created at temperature below the boiling point and of lesions created above the boiling point using High Intensity Focused ultrasound’, J. Biomedical Science and Engineering, 3, 763-775, 2010.
  25. Hadjisavvas V., Ioannides K., Komodromos M., Mylonas N., Damianou C., ‘Evaluation of the contrast between tissues and thermal lesions in rabbit in vivo produced by high intensity focused ultrasound using fast spin echo MRI sequences’, J. Biomedical Science and Engineering, 4, 51-61, 2010.
  26. Couppis A., Damianou C., Kyriakou P., Lafon C., Chavrier F., Chapelon JYy, Birer A.’Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance’, Ultrasonics, 52, 821-829, 2012.
  27. Yiallouras C., Mylonas N., Damianou C. ‘MR compatible positioning device for guiding a Focused ultrasound system for transrectal treatment of prostate cancer’, Computer-Assisted Radiology and Surgery, Vol. 4,Page 745-753, 2014. DOI 10.1007/s11548-013-0964-x 2013.
  28. Damianou C., Christofi C., Mylonas N., Simulation of the Thermal and Mechanical Effects of a Planar Rectangular High Intensity Ultrasound Transducer to Be Used for Destroying Atherosclerotic Plaque Engineering, 2013, 5, 347-351, http://dx.doi.org/10.4236/eng.2013.510B070.
  29. Mylonas N., Damianou C. ‘A Prototype MR Compatible Positioning Device for Guiding a Focused Ultrasound System for the Treatment of Abdominal and Thyroid Cancer, International Journal of monitoring and surveillance technologies research, October-December, Vol.1 (4), pp. 48-61, 2013.
  30. Damianou C., Mylonas N., Ioannides K., ‘Sonothromblysis in Combination with Thrombolytic Drugs in a Rabbit Model Using MRI-Guidance’, Engineering, 2013, 5, 352-356, http://dx.doi.org/10.4236/eng.2013.510B071
  31. Damianou C., Hadjisavvas V., Ioannides K., ‘In vitro and in vivo evaluation of an MRI-guided focused ultrasound system for dissolving clots in combination with thrombolytic drugs’, J Stroke Cerebrovasc Dis. 2014 Aug;23(7):1956-64. doi: 10.1016/j.jstrokecerebrovasdis.2014.01.028..
  32. Mylonas, N. and Damianou, C.,  MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain diseases. Int. J. Med. Robotics Comput. Assist. Surg., 2014 Mar;10(1):1-10. doi: 10.1002/rcs.1501. Epub 2013 Jun 7.
  33. Damianou C., Hadjisavvas V., Mylonas N., Couppis, A., Ioannides K., ‘MRI-Guided Sonothrombolysis of Rabbit Carotid Artery’, Journal of Stroke and Cerebrovascular Diseases, Vol 23 (2), pp. e113-21, 2014.
  34. Yiallouras C., Damianou C., ’Review of MRI positioning devices for guiding focused ultrasound systems’, Int J Med Robotics Comput Assist Surg, 11 (2); (2014), Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/rcs.1601.
  35. Menikou G, Dadakova T, Pavlina M, Bock M, Damianou C., MRI compatible head phantom for ultrasound surgery. Ultrasonics. 2015, Mar; 57:144-52. doi: 10.1016/j.ultras.2014.11.004. Epub 2014 Nov 20.
  36. Damianou C., Christofi C., Mylonas N., ‘Removing atherosclerotic plaque created using high cholesterol diet in rabbit using ultrasound’, Journal of Therapeutic Ultrasound, (2015) 3:3, DOI 10.1186/s40349-015-0025-8. 
  37. Yiallouras C., Ioannides C., Dadakova T., Pavlina M., Bock M., Damianou C., ‘Three axis MR conditional robot for high intensity focused ultrasound for treating prostate diseases’, Journal of Therapeutic Ultrasound, 2015, 3:2, DOI 10.1186/s40349-014-0023-2.
  38. Epaminonda E, Drakos T, Kalogirou C, Theodoulou M, Yiallouras C, Damianou C.,  MRI guided focused ultrasound robotic system for the treatment of gynaecological tumors, Int J Med Robot. 2016 Mar; 12 (1):46-52. doi: 10.1002/rcs.1653
  39. Yiannakou M, Trimikliniotis M, Yiallouras C, Damianou C. Evaluation of focused ultrasound algorithms: Issues for reducing pre-focal heating and treatment time. Ultrasonics. 65 (2016), pp. 145-153. doi: 10.1016/j.ultras.2015.10.007.
  40. Sagias G., Yiallouras C., Ioannides K., Damianou C., An MRI-conditional motion phantom for the evaluation of high-intensity focused ultrasound protocols, Int J Med Robot. 2016 Sep;12(3):431-41. doi: 10.1002/rcs.1709. Epub 2015 Sep 29.
  41. C. Damianou, A. Couppis, ‘Feasibility study for removing calcified material using a planar rectangular ultrasound transducer, Journal of Ultrasound, 19 (2), pp 115-123, 2016. Doi: 10.1007/s40477-015-0191-0
  42. N. Papadopoulos, C. Damianou, ‘In vitro evaluation of focused ultrasound enhanced TNK-TPA mediated thrombolysis’ Journal of Stroke and Cerebrovascular Diseases, ;25(8):1864-77, 2016. doi: 10.1016/j.jstrokecerebrovasdis.2016.03.051
  43. G. Menikou, C. Yiallouras, M. Yiannakou, C. Damianou, ‘MRI guided Focused Ultrasound Robotic System for the Treatment of bone cancer’, Int J Med Robotics Comput Assist Surg 2017; 13: e1753.
  44. Menikou G., Yiannakou M., Yiallouras C., Ioannides C., Damianou C., ‘MRI-compatible bone phantom for evaluating ultrasonic thermal exposures’, Ultrasonics. 2016 Sep;71:12-9. doi: 10.1016/j.ultras.2016.05.020.
  45. N. Papadopoulos, C. Yiallouras, C. Damianou, The enhancing effect of focused ultrasound on TNK- Tissue Plasminogen Activator induced thrombolysis using an in vitro circulating flow model", J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2891-2899. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.052.
  46.  E. Dall’Ara,M. Boudiffa ,C. Taylor, D. Schug, E. Fiegle, A.J. Kennerley, C. Damianou, G.M. Tozer, F. Kiessling, R. Müller , Longitudinal Imaging of the Ageing Mouse, Mech Ageing Dev. 2016 Dec;160:93-116. doi: 10.1016/j.mad.2016.08.001.
  47. C. Damianou, M. Yiannakou, G. Menikou, C. Yiallouras, ‘MRI guided coupling for a Focused Ultrasound system using a top to bottom propagation’, Journal of Therapeutic Ultrasound, 5(1), 6.  doi: 10.1186/s40349-017-0087-x  
  48. N. Papadopoulos, G. Menikou, M. Yiannakou, C. Yiallouras, K. Ioannides, C. Damianou, ‘Evaluation of a small flat rectangular therapeutic ultrasonic transducer intended for intravascular use’, Ultrasonics 74 (2016), 196–203. doi: 10.1016/j.ultras.2016.10.014
  49. N. Papadopoulos, C. Damianou, ‘Microbubble-based sonothrombolysis using a planar rectangular ultrasonic transducer’, Journal of Stroke and Cerebrovascular Diseases, 26 (6), 1287-1296, 2017.
  50. M. Yiannakou, G. Menikou C. Yiallouras, K. Ioannides, C. Damianou, MRI guided focused ultrasound robotic system for animal experiments, the International Journal of Medical Robotics and Computer Assisted Surgery, 13(4), e1804 2017. DOI: 10.1002/rcs.1804 
  51. G. Menikou, C. Damianou, ‘Acoustic and thermal characterization of agar based phantoms used for evaluating focused ultrasound exposures’, Journal of Therapeutic Ultrasound  (2017) 5:14. doi: 10.1186/s40349-017-0093-z 
  52. T. Alecou, M. Yiannakou, C. Damianou, ‘Amyloid beta plaque reduction with antibodies crossing the blood brain barrier opened in 3 sessions with focused ultrasound in a rabbit model’, Journal of ultrasound in medicine 36 (11), 2257-2270, 2017. doi: 10.1002/jum.14256 
  53. G. Menikou, M. Yiannakou, C. Yiallouras, C. Ioannides, C. Damianou, ‘MRI-compatible breast/rib phantom for evaluating ultrasonic thermal exposures’, The International Journal of Medical Robotics and Computer Assisted Surgery 14(1), 2017. DOI: 10.1002/rcs.1849 
  54. N. Papadopoulos, C. Damianou, ‘Microbubble-based sonothrombolysis using a planar rectangular ultrasonic transducer’, Journal of Stroke and Cerebrovascular Diseases, 26 (6), 2017. DOI: 10.1016/j.jstrokecerebrovasdis.2017.01.023 
  55. C. Yiallouras, G. Menikou, M. Yiannakou, C. Damianou, ‘Software that controls a magnetic resonance imaging compatible robotic system for guiding high-intensity focused ultrasound therapy, Digital Medicine, 3(3), 123-132 July-September 2017 DOI: 10.4103/digm.digm_19_17 
  56. C. Yiallouras, M. Yiannakou, G. Menikou, C. Damianou, A multipurpose positioning device for magnetic resonance imaging-guided focused ultrasound surgery, Digital Medicine, 3(3), 138-144 July-September 2017. DOI: 10.4103/digm.digm_33_17
  57. C. Damianou, M. Yiannakou, C. Yiallouras, G. Menikou, ‘The role of 3-D printing in MRI guided focused ultrasound surgery’, Digital Medicine, 4(1), 22-26, 2018.
  58. Giannakou M, Yiallouras C, Menikou G, Ioannides C, Damianou C. MRI‐guided frameless biopsy robotic system with the inclusion of unfocused ultrasound transducer for brain cancer ablation. Int J Med Robotics Comput Assist Surg. 2019; 15: e1951. https://doi.org/10.1002/rcs.1951 
  59. Drakos T, Giannakou M, Menikou G, Ioannides C, Damianou C, ‘An improved method to estimate ultrasonic absorption in agar-based gel phantom using thermocouples and MR thermometry’. Ultrasonics. 2020,  Jan 31;103:106089. doi: 10.1016/j.ultras.2020.106089 
  60.  Christakis Damianou, Marinos Giannakou, Nikolas Evripidou, Stefan Kege, Peter Huber, Juergen Jenne, ‘Focused ultrasound robotic system for very small bore magnetic resonance imaging’, Int J Med Robotics Comput Assist Surg, 16 (6), DOI: 10.1002/rcs.2165, 2020. 
  61. Theoharis Drakos, Marinos Giannakou, Georgios Menikou, Christakis Damianou, ‘MRI-guided focused ultrasound positioning system for preclinical studies in small animals’ J Ultrasound Med 2020; 9999:1–10. doi:10.1002/jum.15514. 
  62. M Giannakou, G Menikou, K Ioannides, C Damianou, Magnetic resonance image-guided focused ultrasound robotic system with four computer-controlled axes with endorectal access designed for prostate cancer focal therapy Digital Medicine 6 (1), 32 
  63. C Damianou, M Giannakou, G Menikou, L Ioannou, Magnetic resonance imaging-guided focused ultrasound robotic system with the subject placed in the prone position, Digital Medicine 6 (1), 24. 
  64. Theocharis Drakos Marinos Giannakou Georgios Menikou Georgios Constantinides Christakis Damianou, ‘Characterization of a soft tissue-mimicking agar/wood powder material for MRgFUS applications’, Ultrasonics, Volume 113, May 2021, https://doi.org/10.1016/j.ultras.2021.106357. 
  65. T Drakos; M Giannakou; G Menikou; A Filippou; N Evripidou; K Spanoudes; L Ioannou; C Damianou, MRI-Guided Focused Ultrasound Robotic System for Preclinical use, J Vet Med Animal Sci. 2020; 4(1): 1049. 
  66. Anastasia Antoniou, Nikolas Evripidou, Marinos Giannakou, Georgios Constantinides, Christakis Damianou, ‘Acoustical properties of 3D printed thermoplastics’, Journal of acoustical society of America (JASA), 2021, 149 (4). https://doi.org/10.1121/10.0004772 
  67. Anastasia Antoniou, Theocharis Drakos, Marinos Giannakou, Nikolas Evripidou, Leonidas Georgiou, Theodora Christodoulou, Natalie Panayiotou, Cleanthis Ioannides, Nikolaos Zamboglou, Christakis Damianou, ‘Simple methods to test the accuracy of MRgFUS robotic systems’, Int J Med Robot. 2021;e2287, https://doi.org/10.1002/rcs.2287. 
  68. Anastasia Antoniou, Marinos Giannakou, Nikolas Evripidou, Georgios Evripidou,  Kyriakos Spanoudes, Georgios Menikou, Christakis Damianou, ‘Robotic system for magnetic resonance guided focused ultrasound ablation of abdominal cancer’, Int J Med Robotics Comput Assist Surg, DOI: https://doi.org/10.1002/rcs.2299. 
  69. Spanoudes K, Evripidou N, Giannakou M, Drakos T, Menikou G, Damianou C. A high intensity focused ultrasound system for veterinary oncology applications. J Med Ultrasound 2021; 29(3):195-202, DOI: 10.4103/JMU.JMU_130_20. 
  70. Panayiota Karanicola, Maria Patsalou, Panagiota-Yiolanda Stergiou, Alexandra Kavallieratou, Nikolas Evripidou, Panagiotis Christou, George, Panagiotou, Christakis Damianou, Emmanuel M. Papamichael, Michalis, Koutinas, ‘Ultrasound-assisted dilute acid hydrolysis for production of essential oils, pectin and bacterial cellulose via a citrus processing waste biorefinery’, Bioresource Technology, DOI: https://doi.org/10.1016/j.biortech.2021.126010 
  71. Anastasia Antoniou, Christakis Damianou, Review of MR relaxation properties of tissue-mimicking phantoms, Ultrasonics, Volume 119, 2022, https://doi.org/10.1016/j.ultras.2021.106600. 
  72. Antria Filippou, Christakis Damianou, Evaluation of ultrasonic scattering in agar‑based phantoms using 3D printed scattering molds, Journal of Ultrasound, https://doi.org/10.1007/s40477-021-00630-7 
  73. Anastasia Antoniou,Marinos Giannakou,Nikolas Evripidou,Stylianos Stratis,Samuel Pichardo,Christakis Damianou, Robotic system for top to bottom MRgFUS therapy of multiple cancer types, , Int J Med Robotics Comput Assist Surg https://doi.org/10.1002/rcs.2364 
  74. Anastasia Antoniou, Leonidas Georgiou, Theodora Christodoulou, Natalie Panayiotou, Cleanthis Ioannides, Nikolaos Zamboglou, Christakis Damianou, MR relaxation times of agar-based tissue mimicking phantoms, Journal of Applied Clinical Medical Physics, Vol. 23 (5), 2022. DOI10.1002/acm2.13533. 
  75. Michalis Sotiriou, Marinos Giannakou, Christakis Damianou, ‘Investigating atherosclerotic plaque phantoms for ultrasound therapy’, Journal of Ultrasound, Vol 25 (3), 709-720, https://doi.org/10.1007/s40477-022-00658-3. 
  76. Filippou, A., Damianou, C. Experimental evaluation of high intensity focused ultrasound for fat reduction of ex vivo porcine adipose tissue. J Ultrasound (2022). https://doi.org/10.1007/s40477-022-00663-6. 
  77. Antria Filippou, Christakis Damianou, ‘Ultrasonic attenuation of canine mammary tumours,’ Ultrasonics, Volume 125, 2022, https://doi.org/10.1016/j.ultras.2022.106798.
  78. Antoniou A, Giannakou M, Georgiou E, Kleopa KA, Damianou C. Robotic device for transcranial focussed ultrasound applications in small animal models. Int J Med Robot. 2022 Aug 3:e2447. doi: 10.1002/rcs.2447. Epub ahead of print. PMID: 35924335 
  79. Marinos Giannakou; Anastasia Antoniou; Christakis Damianou, ‘Preclinical robotic device for magnetic resonance imaging guided focussed ultrasound’, The International Journal of Medical Robotics and Computer Assisted Surgery, 2022-10, DOI: 10.1002/rcs.2466 
  80. A Antoniou, C Damianou, ‘Simple, inexpensive, and ergonomic phantom for quality assurance control of MRI guided Focused Ultrasound systems’, Journal of Ultrasound, 2022.  DOI10.1007/s40477-022-00740-w 
  81. T Drakos, G Evripidou, C Damianou, ‘An in vitro model for experimental evaluation of sonothrombolysis under tissue-mimicking material conditions’, Journal of Medical Ultrasound, 2022. 
  82. Antoniou, Anastasia, Georgiou, Leonidas, Evripidou, Nikolas. Ioannides, Cleanthis, Damianou, Christakis, ‘Challenges regarding MR compatibility of an MRgFUS robotic system’, Journal of Magnetic Resonance, doi: 10.1016/j.jmr.2022.107317 
  83. Filippou, Antria, Evripidou, Nikolas, Damianou, Christakis, 'Robotic system for magnetic resonance imaging-guided focused ultrasound treatment of thyroid nodules', The Int J Med Robot, https://doi.org/10.1002/rcs.2525 
  84. Antoniou, A. Nikolaou, A., Georgiou, A, Evripidou, N, Damianou, C, ‘Development of an US, MRI, and CT imaging compatible realistic mouse phantom for thermal ablation and focused ultrasound evaluation’, Ultrasonics, Vol. 131. DOI: 10.1016/j.ultras.2023.106955 
  85. Anastasia Antoniou, Anastasia Nikolaou, Nikolas Evripidou, Andreas Georgiou, Antria Filippou, Vasiliki Zinonos, Marinos Giannakou, Antreas Chrysanthou, Cleanthis Ioannides, Christakis Damianou, ‘. Phantom-based assessment of motion and needle targeting accuracy of robotic devices for magnetic resonance imaging-guided needle biopsy’, The Int J Med Robot, https://doi.org/10.1002/rcs.2526 
  86. Antria Filippou, Andreas Georgiou, Anastasia Nikolaou, Nikolas Evripidou, Christakis Damianou, Advanced software for MRgFUS treatment planning, Computer Methods and Programs in Biomedicine, Volume 240, 2023, https://doi.org/10.1016/j.cmpb.2023.107726 
  87. Antoniou, A., Stavrou, M., Evripidou, N. et al. FUS-mediated blood–brain barrier disruption for delivering anti-Aβ antibodies in 5XFAD Alzheimer’s disease mice. J Ultrasound (2023). https://doi.org/10.1007/s40477-023-00805-4. 
  88. Antoniou, Anastasia; Damianou, Christakis*. Feasibility of Ultrasonic Heating through Skull Phantom Using Single-element Transducer. Journal of Medical Ultrasound 32(1):p 32-40, Jan–Mar 2024. | DOI: 10.4103/jmu.jmu_3_23: 
  89.  Antoniou A, Evripidou N, Giannakou M, Damianou C. The first magnetic resonance imaging compatible 3D printer. Digit Med. 2024;  doi: 10.1097/DM-2024-00006.

Grants

C. Damianou participated in several grants related to:

  • MR compatible robotics.
  • Ultrasound Phantom development.
  • Industrial ultrasonics.
  • Basic research in Focused ultrasound.

Teaching

Bioengineering and Bioinformatics(EEN 232)

An introduction to the field of bioengineering, including the application of engineering principles and methods to problems in biology and medicine and the integration of engineering with biology. Application of analytic methods from Statistics, Mathematics and Computer Science to biological data so as to extract useful knowledge. Introduction to Bioinformatics. Pairwise sequence alignment and multiple sequence alignment algorithms. Statistical significance of alignment results. Phylogenetic prediction. Database searching for similar sequences, efficiency of relevant algorithms. Protein classification and structure prediction. Statistical analysis of DNA microarray experimental data. Special topics include, biomechanics and biomaterials, bioprocessing and telemedicine, biomedical instrumentation, signal processing and imaging modalities. Introduction to the emerging medical devices industry.

 

Introduction to Medical Imaging (EEN 311)

The course examines the physical principles of the main types of medical imaging such as ultrasound, X-ray imaging, computed tomography (CT), magnetic resonance imaging (PET), SPECT, and positron emission tomography (PET). In ultrasonography emphasis will be given on issues such as interaction of ultrasound and soft tissue, Doppler ultrasound, artifacts, design of ultrasonic transducers and wave equations. In X-rays emphasis will be given on interaction of X-ray and soft tissue, X-ray tube design, Fluoroscopy, Mastography, and Digital subtraction Angiography. In MRI emphasis will be given on issues such as creation of magnetization, resonance, MRI hardware, imaging in 2 dimensions, slice selection, fast sequences, K-space, functional MRI, PWI, DWI, and MRI spectroscopy.

Χριστάκης Δαμιανού
Τεχνολογικό Πανεπιστήμιο Κύπρου
Καθηγητής

Christakis Damianou received a B.Sc., M.Sc., and Ph.D. from the University of Arizona in Electrical engineering in 1988, 1990 and 1993 respectively. He was employed at the universities of Arizona, Indiana, Harvard and Frederick University. Since he returned to Cyprus (1995) his goal was to create a competitive laboratory in MRI guided focused ultrasound surgery.

Christakis Damianou joined Cyprus University of Technology in 2012 and he is currently full professor at the department of Electrical engineering. He teaches courses in the area of biomedical engineering (bioengineering, and medical imaging). His research interests include MRI guided therapeutic ultrasound and MRI compatible robotics.

So far he was involved in 47 research programs, having the scientific coordination of 29 of them. Based on his research activities he published 216 scientific papers (90 of them are peer-reviewed) and 3 book chapters. Currently 3 Ph.D. students are working under the supervision of Dr. Damianou. So far 10 Ph.D. students have graduated under his supervision. 

Since 1990 he is involved in the area of MRI guided Focused Ultrasound (MRgFUS) for medical applications. He is the co-inventor of MRgFUS which is a technology with many medical products globally. Intense ultrasound causes high temperatures (60-100 oC). Therefore this modality can be used to destroy cancer cells. This technology is focused and therefore only a specific target is destroyed, leaving the surrounding tissue unaffected. This technology was never commercialised in the past because there was no effective imaging method to monitor the therapy. Recently with the utilization of MRI, the heating due to ultrasound can be reliably monitored. The technology of MRgFUS is considered the best ablating modality of deep-seated targets and therefore is becoming an effective and attractive engineering-based surgical procedure.

Κύπρος
christakis.damianou@cut.ac.cy
25002039

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